Strengthen the deep integration of scientific and technological innovation and industrial innovation

  Author: Chen Tao (Hefei Institute of Material Science, China Academy of Sciences); Wan Jinbo (China Academy of Sciences Technology Strategy Consulting and Research Institute)

  Core view

  To speed up the cultivation and development of new quality productive forces is to promote industrial innovation with scientific and technological innovation, apply scientific and technological innovation achievements to specific industries and industrial chains in time, transform and upgrade traditional industries, cultivate and expand emerging industries, lay out and build future industries, improve the modern industrial system, and achieve high-quality development.

  Scientific and technological innovation is the core element of developing new-quality productive forces, and pillar industries are the main positions of developing new-quality productive forces. Scientific and technological innovation and industrial innovation demand each other and promote each other. Scientific and technological innovation is the source of industrial innovation, which is driven by industrial innovation and human pursuit of a better life. To speed up the cultivation and development of new quality productive forces is to promote industrial innovation with scientific and technological innovation, apply scientific and technological innovation achievements to specific industries and industrial chains in time, transform and upgrade traditional industries, cultivate and expand emerging industries, lay out and build future industries, improve the modern industrial system, and achieve high-quality development.

  First, strengthen the national strategic scientific and technological strength.Major original and leading scientific and technological innovation is the source of developing new quality productivity. The scientific and technological innovation system led by the national strategic scientific and technological strength focuses on the national strategic needs, and at the same time, it is derived to promote the overall promotion of pillar industries, the cultivation of emerging industries and future industries. The first is to select topics around the national strategic needs. National strategic scientific and technological forces, such as national laboratories, national scientific research institutions, high-level research universities and leading scientific and technological enterprises, focus on major scientific and technological issues that affect and restrict economic and social development and national security, turn the list of issues into a list of tasks, and tackle key problems in basic frontier fields such as quantum technology, information and integrated circuits, artificial intelligence, life and health, biological breeding, aerospace and ocean, advanced materials and manufacturing, new energy, resources and environment. The second is to focus on strategic tasks and innovate organizational models. Focusing on strategic needs, we will form major scientific and technological research projects, build a research system that matches tasks and projects, select strategic scientists from a global perspective, gather superior forces to carry out cross-disciplinary and interdisciplinary collaborative research, and form major original and leading scientific and technological achievements. The third is to optimize resource allocation around strategic objectives. Guided by the optimal allocation of innovative resources, we will carry out strategic-oriented major tasks, achieve breakthroughs in key areas, promote major achievements "laying eggs along the way", and provide strategic, forward-looking and basic scientific and technological innovation support for cultivating new quality productivity.

  Second, strengthen the main position of scientific and technological innovation of enterprises.Enterprises are the key subjects to absorb and create subversive technologies and cutting-edge technologies, gather innovative resources, and cultivate and develop new quality productivity. The first is to guide resource elements to gather in enterprises. Give full play to the role of financial integration in supporting scientific and technological innovation and industrial innovation, and promote the iterative upgrading of standards, rules, brands and values of scientific and technological enterprises. Establish industrial venture capital funds in key areas, actively develop venture capital, attract and incite social capital, expand patient capital, drive more scientific and technological resources to gather in enterprises with strong innovation ability and high innovation efficiency, and promote the innovation and development of enterprises. The second is to support leading enterprises to participate in key core technology research. Focusing on the key core technology of "sticking the neck", we will deploy projects, platforms and tasks in an integrated manner, guide enterprises to participate in major national science and technology projects and key national R&D plans, and accelerate breakthroughs in basic technologies such as key components, parts and basic materials. Promote leading enterprises in science and technology to condense key issues and needs from major application scenarios, form major scientific and technological tasks, and increase the policy and resource guidance for enterprises to participate in topic selection. Third, support leading enterprises to take the lead in organizing collaborative innovation in Industry-University-Research. Give full play to the leading and integrated role of leading enterprises in science and technology, efficiently allocate the elements of innovation resources in Industry-University-Research, unite universities and institutes to form an innovation consortium around key scientific research tasks, drive small and medium-sized enterprises to integrate innovation, and jointly build innovation chain, industrial chain and supply chain in a wider scope to form an innovation cluster.

  Image source: Xinhua News Agency

  Third, strengthen the synergy between scientific and technological innovation and industrial innovation.Improving the overall efficiency of scientific and technological innovation and industrial innovation is an important focus of developing new quality productivity. The first is to strengthen coordination between the central and local governments and between regions. According to the national financial final accounts data, in 2022, the national fiscal expenditure on science and technology was 1,112.84 billion yuan, of which the central and local fiscal expenditure on science and technology accounted for 34.2% and 65.8% respectively. It is necessary to adhere to a national chess game, promote national strategic regional coordination, closely focus on national strategic scientific and technological needs and regional scientific and technological innovation layout, and form effective convergence and overall allocation of resources. The second is to strengthen innovation synergy in Industry-University-Research. The essence of Industry-University-Research’s deep integration is the effective connection and optimal combination of scientific and technological innovation resources and industrial innovation resources. It is necessary to deploy innovation chain around the industrial chain and innovation chain around the industrial chain to enhance the level and competitiveness of science and technology and industrial development. The third is to strengthen the cooperation between business entities and innovation entities. Universities, institutes and enterprises focus on innovation goals, give full play to their respective advantages through task traction, strengthen collaborative innovation between science and technology and industry, bridge the information asymmetry and resource mismatch between R&D and production, and turn innovation advantages into competitive advantages in developing new quality productivity.

  Fourth, strengthen industrial quality and competitiveness.Enhance the flexibility and resilience of the industrial chain and supply chain, and ensure that the industrial chain and supply chain are self-controllable, safe and reliable. First, accelerate the transformation and upgrading of traditional industries. Empower the transformation and upgrading of traditional industries with advanced technology, accelerate cross-border integration and innovation and iterative application of technology, promote the high-end, intelligent and green development of manufacturing industry, and realize the transformation of industrial development from factor-driven and efficiency-driven to innovation-driven The second is to optimize the systematic layout of emerging industries and future industries. Consolidate and expand the leading edge of 5G, intelligent networked new energy vehicles, new energy and other industries, accelerate the development of frontier emerging hydrogen energy, new materials, innovative drugs and other industries, actively create new growth engines such as bio-manufacturing, commercial aerospace and low-altitude economy, and open up new tracks such as "artificial intelligence+",quantum technology and life sciences. Accelerate the tackling of major tasks, combine regional reality, strengthen system layout, highlight characteristic advantages, and form a differentiated development pattern with complementary advantages. The third is to comprehensively improve the level of industrial development. Using advanced technology to empower industrial upgrading, chain owners take the lead in promoting chain building, chain extension, chain supplement and chain strengthening, and drive small and medium-sized enterprises to enter the chain, forming a development pattern of supporting upstream and downstream of the industrial chain, and enhancing the integrity, stability and competitiveness of the industrial chain. Accelerate the cultivation of strategic emerging industrial clusters, fully release the spatial agglomeration effect of knowledge clusters, industrial clusters and innovation clusters, and enhance the influence, radiation and competitiveness of various parks.

  Fifth, build a new production relationship.Scientific and technological innovation and industrial innovation are dynamic and have great uncertainty. To establish a new production relationship that is compatible with the new quality productivity, it is necessary to further deepen the reform in an all-round way and give full play to the decisive role of the market in allocating resources, the guiding role of government policies such as science, technology and industry, and the linking role of social mechanisms. The first is to strengthen the traction of innovation and development goals. Clarify the strategic objectives of regional scientific and technological innovation and industrial innovation to support the construction of a strong country in science and technology and an economic power, refine the measurement indicators and action plans, form a basic system to support comprehensive innovation, and provide institutional guarantee for the development of new quality productive forces. The second is to promote scientific and technological innovation, industrial innovation and institutional innovation. Around the logic of scientific and technological innovation, industrial innovation market logic and capital logic, we will build a high-standard national unified market, create a good innovation ecology and business environment, open up the blocking points and blocking points of the flow of production factors, and smooth the virtuous circle of "science and technology-industry-finance". The third is to deepen the reform of economy, education, science and technology, talents and other systems. Strengthen the consistency between reform and macro-policy orientation, deepen the comprehensive reform of educational science and technology talents, and work together with economic system reform and supply-side structural reform to form a joint force. Promote the integration of production and education, science and education, cultivate more strategic scientific and technological talents, leading scientific and technological talents and innovative teams, and transform the advantages of regional scientific and technological education talents into new kinetic energy and advantages for innovation and development.

The premiere of "See Lotus Again" shows the 20th anniversary of Macao’s return.

Special feature of 1905 film network On December 20th, to celebrate the 20th anniversary of Macao’s return to China, a film jointly produced by the Program Center of the Film Channel and iQiyi Beijing Technology Co., Ltd. will be broadcast simultaneously on CCTV-6 Film Channel and iQiyi website.

"You know Macau is not my real name. I have been away from you for too long, mother." The melodious melody of Song of Seven Sons still lingers in our ears. In a blink of an eye, Macao has returned to the embrace of the motherland for 20 years.

What kind of 20 years is this? In the long river of history, it may just be a drop in the ocean, but for every Chinese, the "Mama Port" that has been swept away from historical humiliation has opened a new era of prosperity and development.

The film See Lotus again, jointly produced by the Program Center of Film Channel and iQiyi, is a specially customized work to celebrate the 20th anniversary of Macao’s return.

The film is starring Yang Xuchen, Hei Lui, Bruce Lee and Yang Lei, written by Liu Hua and Yuan Wei, and directed by Yuan Wei and Tony Gao. Under the grand theme, See Lotus again shows the development and changes of local social life since Macao’s return from different perspectives, such as bosom friend, mentor, father and son, by describing a series of stories that happened in Mazu statue carving family.

The statue carving in Macao originated from the folk beliefs of local fishermen and has a history of more than 400 years. It is the first project in Macao to win the honorary title of "National Intangible Cultural Heritage". Today, it not only represents Macao’s human history, but also entrusts Macao people’s yearning for a peaceful and peaceful life.

The imaginative use of "sculpture" in See Lotus again has contributed to the "fate" between Liao Jichang, a sculptor of Macao gods, and Gu Songlin, a sculptor living in Beijing. The inspiration for the creation comes from an interview with Mr. Guo Baozhai, a famous sculptor of the Central Academy of Fine Arts, who is the prototype of the statue of "Prosperous Lotus" in Macao: "Prosperous Lotus" was a gift from the central government to the Macao SAR government and to the Hong Kong SAR in 1999.

Because of this "Lotus in Prosperity", Liao Jichang and Gu Songlin have not only become "friends with swords" and bosom friends of appreciate each other, but their 20-year-long friendship has also witnessed the rapid changes in the local area.

In See the Lotus again, the creators use some ingenious details to turn the daily life of the little people into a special footnote of the great era. For example, Gu Songlin traveled back and forth between the mainland and China several times in 20 years, and this time he told Liao Jichang that he chose to take the bus specially in order to personally feel how convenient the newly completed "Hong Kong-Zhuhai-Macao Bridge" was.

In addition to the friendship passed down from father to father, See Lotus also takes care of the growth of young people in Macao. From Liao Zihao, the inheritor of the idol carving family, and Ajia, a girl who runs a dessert shop independently, we can not only see the vitality of Macao, but also contact ourselves and find the momentum and resonance of the struggle for life among the same generation.

General Secretary of the Supreme Leader once suggested during his inspection in Macao that "Song of Seven Sons" "can always hear new ideas and be deeply moved". This is also a true portrayal of Macao’s return to the motherland for 20 years: the wanderers’ attachment to their motherland has never changed, and the successful practice of "one country, two systems" with Macao characteristics has continuously injected new vitality into Macao.

At the end of the film See Lotus Again, Liao Jichang and Gu Songlin overlook the streets and lanes of the city and feel the real influence and changes brought by "one country, two systems" to Macao. They have walked together and witnessed for 20 years, and the "tomorrow" of Macao will be left to young people to continue to describe and create.

At 20: 15 pm on Friday, December 20th, let’s experience the great difference of the 20th anniversary of Macao’s return to China in See the Lotus again!


Win the tough battle of supply-side structural reform (new ideas, new ideas and new strategies for governing the country)

  In November 2015, when the Supreme Leader presided over the 11th meeting of the Central Financial and Economic Leading Group, he stressed that while moderately expanding the total demand, efforts should be made to strengthen the structural reform of the supply side, improve the quality and efficiency of the supply system, enhance the momentum of sustained economic growth, and promote the overall leap of China’s social productivity level. This is the first time that the supreme leader comrade has put forward a major proposition of supply-side structural reform. The Central Economic Work Conference held at the end of 2015 clarified the key tasks of supply-side structural reform "three to one, one reduction and one supplement". The Central Economic Work Conference held at the end of 2016 and the important speeches made by the top leaders at the 38th collective study in the Political Bureau of the Central Committee and the 15th meeting of the Central Financial and Economic Leading Group further enriched the theoretical and practical connotation of the supply-side structural reform, and provided scientific guidance for further promoting the supply-side structural reform. The supply-side structural reform is connected with the new normal of economic development, and the other is connected with the reform of economic system, which has deepened the reform in an all-round way and integrated development and reform. The implementation for more than a year has significantly promoted the adjustment of China’s economic structure and promoted the quality and efficiency of development. Comrade Supreme Leader profoundly pointed out that the structural reform on the supply side is a tough battle with a long-term relationship with the overall situation. We should further deepen our understanding of supply-side structural reform, firmly grasp the main line of supply-side structural reform, and strive to win this tough battle.

  Continuous development: actively adapting to and leading the new normal of economic development

  Since the 18th National Congress of the Communist Party of China, under the background of profound changes in the economic situation at home and abroad, the CPC Central Committee with the Supreme Leader as the core has made a major judgment that China’s economic development has entered a new normal in due course. The word "new" just reveals that the economic environment we are in is very different from the past. Understanding, grasping and leading the new normal has become the great logic of doing a good job in economic work at present and in the future. Judging the economic situation with the big logic of the new normal will find that:

  Since we are facing the new normal of economic development instead of the old normal, it is the only choice to embark on a new way of economic work and build a new pattern of macroeconomic regulation and control based on the realistic national conditions that China’s economy is evolving to a more advanced stage with more complicated division of labor and more reasonable structure.

  Since the prominent contradictions and problems faced by China’s current economic operation are mainly caused by structural factors, which are not cyclical factors and aggregate factors, the economic cycle is not smooth due to major structural imbalances; There are structural problems on both sides of supply and demand, but the main aspect of contradictions is on the supply side. So, focusing on solving these outstanding contradictions and problems that are very different from the past and finding a way out from the supply side and structural adjustment will of course become a new focus of macroeconomic policy.

  Since the fundamental cause of these major structural imbalances lies in institutional obstacles, in the failure of the market to fully play a decisive role in resource allocation, and in the failure to better play the role of the government, it is undoubtedly a new foothold for macroeconomic policies to break through institutional obstacles and achieve a new dynamic balance between supply and demand by means of reform.

  These changes can be summed up as follows: compared with the previous macro-economic management based on aggregate adjustment and focusing on the demand side, and mainly relying on policy operation, the macro-economic management under the new normal should be based on structural adjustment and focus on the supply side, and be implemented mainly through reform.

  The major proposition of supply-side structural reform is formed and evolved into the main line of economic work under such conditions and based on such scientific judgment. That is to say, supply-side structural reform is closely linked to the new normal of economic development. It is precisely because economic development has entered a new normal that supply-side structural reforms must be implemented; Supply-side structural reform can only be truly implemented if it is based on adapting to and leading the new normal of economic development.

  One-stop reform: traction and promotion of comprehensive deepening reform

  Standing at a new historical starting point, the biggest difference between the comprehensive deepening reform deployed by the Third Plenary Session of the 18th CPC Central Committee and the previous reforms is that it is not a reform in a certain field, nor a reform in a few fields, but a reform covering economic system, political system, cultural system, social system, ecological civilization system and other fields, involving both productive forces and relations of production, economic base and superstructure. It is systematic, holistic and coordinated. Setting the direction, choosing the key points, seeking the layout, and promoting the reform in important areas and key links as a whole around enhancing the systematicness, integrity and synergy of reform are obviously the central issues that cannot be avoided and bypassed in comprehensively deepening reform.

  Since it is a comprehensive reform, it is necessary to make an overall plan for what the reform in various fields is ultimately for and what kind of overall effect it will achieve. In view of the fact that comprehensive deepening reform involves a series of institutional and institutional transformations, each reform will affect or affect other reforms, and each reform also needs the cooperation of other reforms. The goal put forward around comprehensive deepening reform cannot only cover one or a few fields, but should cover all fields and dominate all fields. Therefore, the Third Plenary Session of the 18th CPC Central Committee established "perfecting and developing the Socialism with Chinese characteristics system and promoting the modernization of the national governance system and governance capacity" as the overall goal of comprehensively deepening reform.

  Since we are aiming at such an overall goal to deepen the reform in an all-round way, we need to choose the breakthrough point and main clue in the linkage and integration of reforms in various fields and promote them with emphasis. China’s reform focuses on the reform of the economic system, and comprehensively deepening the reform is initiated on the basis of the remarkable achievements in the economic system reform and the establishment of the socialist market economic system. No matter from which aspect, in order to achieve the overall effect of reform and form the overall effect of reform in the linkage of economic, political, cultural, social and ecological civilization, so as to realize the modernization of state governance, economic system reform is still a reform field with "bull’s nose" effect. This means that to comprehensively deepen reform, we should take economic system reform as the focus of traction and promotion of reforms in various fields.

  Now that we have entered the new normal of economic development and noticed the objective fact that the new normal of economic development is closely related to the supply-side structural reform, it is not difficult to find that both the promotion of economic system reform and the comprehensive deepening of reform are inseparable from the supply-side structural reform. Information from all sides also shows that most of the key points and difficulties in China’s current economic system reform are either on the supply side or on the structure, which are intertwined with the supply side and structural problems. For example, the core issue of economic system reform is to properly handle the relationship between the government and the market, so that the market can play a decisive role in resource allocation and better play the role of the government. Among them, whether it is the role of the market in resource allocation, the role of the government, or the coordination of the two, it is a supply-side and structural issue. It can be seen that to promote comprehensive and deepening reform with the focus on economic system reform, we can only and must start from the supply-side structural reform and start around the main line of supply-side structural reform; Reform and development can only and must be closely linked, seeking development through reform and seeking reform through development.

  Structural reform from the supply side — Economic system reform — It can be clearly seen from the relationship chain of comprehensive deepening reform that we should continue to deepen the economic system reform with the supply-side structural reform as the main line, and further promote the "three to one, one reduction and one supplement" with reform methods, take deepening decentralization, combining management with optimization of service reform as the important content of the supply-side structural reform, and continuously increase the effective supply including institutional supply, which is the only way for us to promote comprehensive deepening reform under the new normal of economic development.

  Preventing "Old Wine in New Bottles": Deepening the structural reform of supply side must rely on new ideas, new ideas and new strategies.

  The supply-side structural reform integrates development and reform, which not only reflects the requirements of the economic policy framework that adapts to the new normal of economic development, but also connects with the overall deployment of comprehensively deepening reform. Supply-side structural reform is a major innovation to adapt to and lead the new normal of economic development, and an active choice to adapt to the new situation of comprehensive national strength competition after the international financial crisis. It is extremely important and crucial to win the supply-side structural reform, which has a bearing on the overall situation and the long-term battle.

  It is not easy to further deepen the supply-side structural reform under the background of the new normal of economic development and comprehensive deepening reform. In view of the changes in the prominent contradictions and problems we are facing, one problem that needs special attention and key prevention at present is "old wine in new bottles" — — Use inertial thinking to face the new situation and copy customary practices to deal with new problems; At present, an extremely important and urgent task is to comprehensively and systematically adjust the ideas, thoughts and strategies that were used to in the past, unify thoughts and actions into the major policies and decision-making arrangements of the CPC Central Committee, and promote and deepen the supply-side structural reform under the guidance of the new ideas, new ideas and new strategies of the CPC Central Committee for governing the country.

  For example, go to capacity. De-capacity, which ranks first in the five major tasks of supply-side structural reform, cannot be equated with the previous "de-capacity", and it cannot be implemented by government administrative means. Overcapacity is the root of all contradictions and problems, and resolving the problem of overcapacity is a major issue that cannot be bypassed in any case. However, de-capacity should and must be based on market regulation and focus on improving the institutional mechanism that makes the market play a decisive role in resource allocation.

  For example, reducing costs. It should be recognized that the main purpose of reducing the tax burden of enterprises at present is to reduce the cost of enterprises and improve the quality of supply. It is a structural adjustment rather than a total adjustment, and the focus falls on the supply side rather than the demand side. Therefore, tax reduction and fee reduction must not follow the previous "borrowing money" routine — — By expanding the deficit and issuing additional treasury bonds to support tax reduction and fee reduction, we should implement the linkage between tax reduction and fee reduction and government expenditure reduction, so as to make room for enterprises to reduce the tax burden by reducing the scale of government expenditure. Only in this way can the tax burden of enterprises be truly reduced and the pattern of resource allocation be changed in favor of enterprises.

  For example, make up the short board. As one of the important tasks of supply-side structural reform, we must not simply adopt the method of "adding more water to the surface and adding more water to the surface", but should recognize that the trade-off between manufacturing and service industries is a regular change in industrial structure; Nor can we simply start with maintaining growth and expanding investment, but we should realize that improving people’s livelihood and doing a good job of basic people’s livelihood protection are important areas that need the government to play a better role. The short board should be based on the new normal of economic development, cut in from the important areas and key links that seriously restrict economic and social development, and cut in from the outstanding problems that the people urgently need to solve, which not only complements the hard short board but also complements the short board of development and system.

  Such as macroeconomic policies. In view of the fact that we have initially formed a policy system with the new development concept as the guide and the supply-side structural reform as the main line, the supply-side structural reform must not be satisfied with the previous paradigm of "acting against the wind" — — We should tighten when the economy is overheated and expand when it is cold. Instead, we should get rid of the limitations of policy adjustment, skillfully combine policy adjustment with institutional arrangements, and realize a new dynamic balance between supply and demand through reform.

  The above examples are intended to show that the new normal of economic development is different from the old normal of economic development, comprehensive deepening reform is different from simple economic system reform, and supply-side structural reform is different from demand management and regulation. Only by promoting and deepening the supply-side structural reform under the guidance of the new ideas, new ideas and new strategies of the Party Central Committee in governing the country can we win this tough battle, and promote the implementation of economic policies that adapt to the new normal of economic development and comprehensively deepen the realization of reform goals, thus promoting the development of China’s economy in a higher quality, more efficient, fairer and more sustainable direction.

  (The author is Gao Peiyong, a member of the Chinese Academy of Social Sciences and a researcher at the Socialism with Chinese characteristics Theoretical System Research Center)

The Flowers of Women Bloom in a New Era —— On-the-spot Report of the CPC Central Committee with the Supreme Leader as the Core to Promote the Development of Women’s Cause

  Fanghua, blooming in the sun; Women, show the style of the times.

  Since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has been concerned about the all-round development of women, planning and deploying to promote women’s work, and encouraging hundreds of millions of women to hold their heads high, struggle and dream on the new journey of realizing the great rejuvenation of the Chinese nation.

  "The cause of women has always been an important part of the cause of the party and the people."

  On February 25, 2021, the Great Hall of the People in Beijing. The national summary and commendation meeting for tackling poverty was grandly held here.

  On the podium, General Secretary of the Supreme Leader leaned over and solemnly awarded the medal to Zhang Guimei, who was in a wheelchair.

  "Take care of yourself!" The general secretary said with concern.

  Despite her illness, Zhang Guimei, the principal of Huaping Girls’ High School in Lijiang, Yunnan Province, has held up more than 2,000 girls’ dreams of studying in mountainous areas with her hands for more than 10 years. The general secretary praised her deeds: "Dedicated to education and poverty alleviation, igniting the hope of Dashan girls".

  More than four months later, she used these plastered hands to "hold" the "July 1st Medal" representing the highest honor in the Party.

 On the first day of the college entrance examination in 2023, Zhang Guimei, the principal of Huaping Girls’ High School in Lijiang, Yunnan, watched the students enter the exam outside the test center (photo taken on June 7, 2023). Xinhua News Agency reporter Jiang Wenyao photo

  In the name of the country, pay tribute to the hero. On the journey of Chinese modernization, the dazzling light of women’s model shines; In the history of the Republic, the outstanding feats of "Half the Sky" are engraved!

  "Our party has led the people in the glorious course of unremitting struggle, and every victory has the active participation and outstanding contribution of the majority of women." The words of the General Secretary of the Supreme Leader are profound.

  For more than 100 years, in various historical periods of revolution, construction and reform, the Communist Party of China (CPC) has always insisted on writing women’s liberation and development and equality between men and women on its own banner of struggle, always regarded women as an important force to promote the development of the cause of the party and the people, always placed women’s work in an important position, opened up the road for women’s development in Socialism with Chinese characteristics, and led women to write a wonderful chapter of sharing their destiny with the motherland and fighting with the people.

  "Women hold up half the sky. How heroic this sentence is! " In the mind of the Supreme Leader’s General Secretary, there is no limit to the strength of women.

  On March 8, 1990, the then Supreme Leader of Ningde District Party Committee Secretary published an article entitled "Women are the Great Force to Promote Social Development — — For the "March 8" International Women’s Day.

  The article writes, "History and reality tell us that women, who account for more than half of the population, are a great force to promote the development of the whole society. The success of each of our undertakings includes the hard work of women. " Between the lines, full of praise and encouragement to women compatriots.

  "Good holidays! You are all very energetic today. "

  On March 8, 2013, during the two sessions of the National People’s Congress, General Secretary of the Supreme Leader paid a cordial visit to women representatives when he participated in the deliberation of the Jiangsu delegation, and said to everyone: "Women representatives are the best among women, and I hope you can give full play to the leading role."

  In the spring of March, women welcome their own festivals. Since the 18th National Congress of the Communist Party of China, every year at this time, the sincere holiday wishes of the Supreme Leader General Secretary will arrive as scheduled.

  General Secretary of the Supreme Leader is very concerned about the development of women’s cause. Based on the present and focusing on the future, the CPC Central Committee with the Supreme Leader as the core has made a series of groundbreaking, overall and long-term major decision-making arrangements:

  "Adhere to the basic national policy of equality between men and women and protect the legitimate rights and interests of women and children" was written in the 18th and 19th National Congress of the Communist Party of China and Report to the 20th CPC National Congress;

  "Pay attention to the construction of family education style and protect the rights and interests of women and children" was written into the third historical resolution of joining the party;

  At the Fourth Plenary Session of the 19th CPC Central Committee, it was clearly put forward that "the system and mechanism for promoting gender equality and women’s all-round development should be adhered to and improved".

  … …

  On October 31st, 2013, when the General Secretary of the Supreme Leader talked with the new leadership of the All-China Women’s Federation, he pointed out the way forward for the development of women’s cause in the new era — —

  "Realizing the goals and tasks put forward by the 18th National Congress of the Communist Party of China and realizing the great rejuvenation of the Chinese nation is the overall work of the Party and the country, and it is also the theme of the times of the contemporary women’s movement in China."

  In the new era and new journey, the development of women’s cause has been endowed with new connotation of the times, and hundreds of millions of women shoulder more important missions.

  At 23: 57 on November 1, 2018, with the successful launch of the 41st Beidou navigation satellite, thunderous applause sounded in the command hall. Colleagues gave Zhang Runhong thumbs up and praised her.

  The sonorous password of this satellite launch was issued by 36-year-old Zhang Runhong. This is the first time in China’s space history that a woman is the commander of "01".

  On the eve of the Spring Festival that year, the General Secretary of the Supreme Leader came to a base of the troops stationed in Sichuan to visit the officers and men. Zhang Runhong, who was in the team, reported his ambition to the General Secretary:

  "Chairman of the report, I still have a goal, which is to become the first woman in China ‘ 01’ Commander. "

  “‘ 01’ Commander, being able to undertake such a heavy scientific research task is also a sign of the cause of women in our country. I also hope that you can achieve your goal as soon as possible. " The general secretary happily encouraged Zhang Runhong.

  Women’s heroes struggle to realize their dreams, and the development of women’s career in the new era shows a new atmosphere.

 In the "Women’s Workshop" in Fengcang Village, Shendingshan Town, Miluo City, Hunan Province, workers are producing data lines (photo taken on March 7, 2023). Xinhua News Agency reporter Chen Si Khan photo

  "We should make unremitting efforts to open up a broad road for the development of women’s cause."

  On April 19th, 2007, the supreme leader comrade served as the secretary of Shanghai Municipal Party Committee for less than one month, and made a special trip to Shanghai Women’s Federation for investigation.

  "As soon as he entered the conference room, he shook hands with each of us first." Recalling the scene of that year, Zhang Lili, then Party Secretary of Shanghai Women’s Federation, still could not hide her excitement.

  "Women hold up half the sky. If we do this half thing well, it will affect the overall situation and the whole." The exhortation of the Supreme Leader made Zhang Lili and other comrades at the meeting feel deeply responsible.

  Love is consistent, and feelings are deep and lasting.

  Since the 18th National Congress of the Communist Party of China, the General Secretary of the Supreme Leader has profoundly pointed out: "Doing a good job in the Party’s women’s work is related to uniting and rallying the broad masses of women who account for half of China’s population, to providing a powerful force for the development of the cause of the Party and the people, and to consolidating the class foundation and mass foundation of the Party’s governance".

  From ensuring women’s basic medical and health services to enhancing women’s ability to participate in political and economic activities; From developing vocational education and lifelong education for women to developing international development cooperation in the field of women; From the formulation of the Outline for the Development of Women in China (2021-2030) to the revision of the Law on the Protection of Women’s Rights and Interests … … The CPC Central Committee with the Supreme Leader as the core has always attached importance to women’s all-round development, leading women to release their creative vitality and realize the value of life.

  "Domestic service is promising" — — In November 2013, the words made by the Supreme Leader General Secretary during his inspection tour in Jinan Comprehensive Service Center for Migrant Workers strengthened the determination of Zhuo Changli, a domestic worker: "The encouragement of the General Secretary made my heart warm up at once!"

  Zhuo Changli (middle) guides the domestic servants who are being trained (photo taken on June 2, 2021). Xinhua news agency

  Care turns into motivation, and expectation inspires action.

  Today, Zhuo Changli founded the "Sunshine Sister" housekeeping service company from Jinan to the whole country, and the number of domestic attendants has grown to more than 70,000. Zhuo Changli and his sisters also changed their destiny and realized their value in the process of serving the society.

  "In the process of China people’s pursuit of a better life, every woman has the opportunity to shine in life and make her dreams come true." Listening to women’s voices, respecting women’s wishes, and the affectionate entrustment of the Supreme Leader General Secretary give women the confidence and strength to pursue their dreams.

  For the training of female cadres, the General Secretary of the Supreme Leader pays special attention to it.

  "That meeting was really good, and the care of the supreme leader comrades became the driving force for us to take the road of life well." Thirty years have passed, and Zhu Hua, a retired female cadre, has always been impressed.

  In 1993, Fuzhou Women’s Federation held a symposium for female cadres and invited the top leader of Fuzhou Municipal Party Committee Secretary to attend the guidance. Comrade Supreme Leader said at the meeting that women’s participation in politics is a sign of social civilization, women’s liberation and the superiority of the socialist system. Accelerating the training of women cadres is the need of speeding up reform, opening up and economic construction, and it is also an important part of the work of our party organization.

  More than 20 female cadres attending the meeting were encouraged, and they successively took up important positions and played a key role through their own efforts.

  "The status of women is one of the important symbols to measure the level of civilization in a society. We should understand the characteristics of women cadres and care for them. I hope that women cadres will establish the spirit of self-esteem, self-confidence, self-reliance and self-improvement and boldly carry out their work. "

  When talking collectively with the members of the new leadership team of the All-China Women’s Federation, he emphasized "caring for their growth and creating a broad stage for more female talents to stand out"; At the 20th National Congress of the Communist Party of China, it was emphasized that "we should attach importance to the training and selection of female cadres and give full play to their important role" … … Since the 18th National Congress of the Communist Party of China, the General Secretary of the Supreme Leader has encouraged and supported women to participate in the practice of economic and social development and contribute to the construction of a strong country and national rejuvenation.

  "Aunt, you are here."

  On the eve of the Lunar New Year in 2016, General Secretary of the Supreme Leader who visited Jinggangshan came to Shende Bookstore in Bajiaolou and recognized Gong Quanzhen as soon as he entered the door.

  More than two years ago, when meeting with the winners of the Fourth National Moral Model and Nomination Award, General Secretary of the Supreme Leader specially introduced to the participants: This doyen is Gong Quanzhen, the wife of the old general Gan Zuchang. She is over 90 years old this year, and I was deeply moved when I saw her.

 Old man Gong Quanzhen (third from left) and children in Lianhua County, Pingxiang City, Jiangxi Province (photo taken on May 21, 2013). Xinhua News Agency reporter Hu Chenhuan photo

  "I had this text when I was a primary school student. The content is that generals are farmers, and we are deeply influenced." General Secretary of the Supreme Leader said that half a century later, Gong Lao still carries forward this spirit, and this spirit of hard struggle should be passed down not only by our generation, but also by the next generation.

  Home is the smallest country, and there are thousands of countries.

  "Women should play a greater role in society and play a key role in the family." The General Secretary of the Supreme Leader pays special attention to the unique role of women in carrying forward the family virtues of the Chinese nation and establishing a good family style, and promotes the harmony of small families to build a harmonious society.

  With the tide of the times rolling forward, how can women’s federations continue to be the "parents" of hundreds of millions of women? How to make women’s work always new and full of vitality?

  In July 2015, the General Secretary of the Supreme Leader presided over the first meeting of the Central Party’s group work in the history of the Party, which opened the curtain of deepening the reform of the Women’s Federation. A year later, the All-China Women’s Federation Reform Plan was issued, and a series of major measures continuously enhanced the political, advanced and mass nature of women’s federations, so that "parents" could speak out when women needed it, defend their rights, and sink into service, and do more practical and good things for women.

  The "Women’s Grand Presentation" covered more than 1.5 billion person-times online and offline, and more than 4,000 national March 8th Red Flag Bearers and a large number of advanced typical transmission role models;

  1.08 million women’s groups and 900,000 "women’s homes" and "women’s micro-homes" are distributed in urban and rural communities; Nearly 7 million executive committees of women’s federations at all levels are active at the grassroots level and serve the majority of women;

  Government cadres regularly go to the grassroots level and go to households to solve practical difficulties for women; The online women’s Federation has been upgraded and developed to create an "online home" for women who are not disconnected for 24 hours;

  … …

  "We should make unremitting efforts to open up a broad road for the development of women’s cause" — — The solemn commitment made by the CPC Central Committee with the Supreme Leader as the core is constantly becoming a beautiful reality.

  "Every woman is a writer of the times and a struggler for dreams."

  The outbreak in COVID-19 was sudden. Liu Jiayi, a "post-00" female nurse of Guangdong medical aid team, plunged into Wuhan in the "storm". She said, "If I wear protective clothing, I won’t be a child."

  This sentence touched China and the world. On October 1, 2020, General Secretary of the Supreme Leader told the world the story of this female nurse at the high-level meeting of the United Nations General Assembly to commemorate the 25th anniversary of the Beijing World Conference on Women — —

  "It is thousands of such women in China, dressed in white and retrograde, who have interpreted the kindness of doctors with courage and hard work, and exchanged their responsibility and dedication for the innocent mountains and rivers."

  State affairs, China women have never been absent. At the critical juncture of fighting the COVID-19 epidemic, in the fiery front line of poverty alleviation and rural revitalization, in the forefront of scientific research … … The vast number of women are selfless, fearless and willing to contribute, and have written magnificent women’s chapters.

  Be a builder of great cause, serve the country and the people, and shine — —

  On July 21st, 2021, General Secretary of the Supreme Leader met Huang Haifen, a post-90s female village official, at the convenience service center in Gala Village, Linzhi City, Xizang.

  Knowing that the Chaoshan girl gave up her white-collar job after graduating from college and settled down in the snowy plateau, the General Secretary of the Supreme Leader encouraged her: "From the coast to the plateau, you need people here. Do a good job here."

  Entrust earnestly, such as spring breeze blowing through the heart. Huang Haifen has no regrets and is determined to spend his youth where the party and the people need it most.

  On September 11th, 2020, at the symposium of scientists, Fu Qiaomei, a female scientist born after 80s who has been engaged in paleogenetics research for a long time, admitted to the General Secretary: "People often ask, ‘ What’s the use of your research ’ . When it was difficult to maintain in the laboratory, I also thought about whether to do a popular research … …”

  After listening to it, the general secretary said with deep feelings: "What do you think of the unpopular? Generally speaking, some unpopular things are useless. This understanding may delay the career in a field. To evaluate scientific research, we must have a long-term vision, a world vision and a scientific vision. "

 Fu Qiaomei, a "post-80s" female scientist who has been engaged in paleogenetics research for a long time, gave a keynote speech at the 3rd China Archaeological Congress held in Sanmenxia City, Henan Province (photo taken on October 18th, 2021). Xinhua News Agency reporter Li Heshe

  Bearing in mind the encouragement of the General Secretary, Fu Qiaomei sat on the "cold bench" and led the team to continue to study in the field of paleogenome research.

  The individual "ego" is integrated into the "ego" of the party and the country, and the majority of women are self-reliant and forge ahead, contributing wisdom and strength to the development of various undertakings in the country.

 Women volunteers from Huyuan Township, Fuyang District, Hangzhou City, Zhejiang Province, promoted local specialty foods and agricultural products at the rural market (photo taken on March 3, 2023). Xinhua News Agency reporter Xu Yushe

  Be an advocate of civilized fashion, carry on the tradition and carry forward the virtues — —

  On the morning of June 29th, 2021, at the Great Hall of the People in Beijing, the Party Central Committee awarded the "July 1st Medal" for the first time.

  "Wang Lanhua, there you go again, again with honor." General Secretary of the Supreme Leader greeted the old man whom he had seen during his visit to Ningxia the year before.

  Wang Lanhua, who is over 70 years old, is a volunteer leader of Jin garden club in wuzhong, Ningxia, and is called "Living Lei Feng" in the community. She said that when encountering difficulties, she often thinks of what the General Secretary said: "Socialism is done".

  From the "Wang Lanhua Enthusiastic Group" with only seven people to the volunteer team with over 95,000 people, Wang Lanhua, who is over 70 years old, led a group of enthusiastic aunts and embarked on an increasingly broad "love avenue".

  "Orchid fragrance", actions speak louder than words.

  In the early morning, Huawu Village, Qianxi City, Guizhou Province was busy. In the non-legacy workshop, embroidered mothers are flying needles and rushing to make a batch of Miao Xiu clothing orders.

 Miao embroidered mothers are making Miao costumes in Huawu Village, Xinren Miao Township, qianxi county, Bijie City, Guizhou Province (photo taken on February 20, 2021). Xinhua News Agency reporter Yang Wenbin photo

  On February 3, 2021, General Secretary of the Supreme Leader came to Huawu Village. Peng Yi, a non-genetic inheritor, told the General Secretary about his experience of returning to his hometown to start a business and develop Miao Xiu skills. The general secretary affirmed: "Miao Xiu is both traditional and fashionable. You embroidered it one by one. How wonderful!"

  Bearing in mind the general secretary’s encouragement that "Miao Xiu must be carried forward", Peng Yi not only provided a platform for local women to learn Miao Xiu skills, but also actively explored the innovative development of Miao Xiu, so as to rejuvenate ancient Miao Xiu.

  Li Jin, Teng Bian, Jia Ya Tibetan Carpet … … In the local investigation and research, the general secretary has had exchanges with many female non-genetic inheritors. Good talk and expectation will inspire women to pass on Chinese excellent traditional culture from generation to generation with confidence.

  Be a struggler who dares to pursue dreams, work hard and make progress — —

  The 2019 Women’s Volleyball World Cup was held in Japan from September 14 to 29. China women’s volleyball team won the championship and successfully defended its title by winning 11 consecutive victories.

  On the occasion of celebrating the 70th birthday of New China, General Secretary of the Supreme Leader specially invited China women’s volleyball team members who just won the championship to attend the National Day reception, and cordially met with women’s volleyball representatives before the meeting. The general secretary praised: "You showed the spirit of the motherland first, unity and cooperation, tenacious struggle and never give up."

  On October 7th, 2023, the China Women’s Volleyball Team achieved another success in the Hangzhou Asian Games, winning the gold medal in the Asian Games for the ninth time with a total victory of six games.

 On October 7th, 2023, the China Women’s Volleyball Team achieved another success in the Hangzhou Asian Games, winning the gold medal in the Asian Games for the ninth time with a total victory of six games. Xinhua News Agency reporter Zhang Tao photo

  Enthusiastic words, earnest entrustment, inspire women’s volleyball girls to dominate the arena, inspire hundreds of millions of women to forge ahead and dream of rejuvenation with the most beautiful posture.

  In 2012, Liu Yang embarked on a flying journey, and women in China wandered the vast universe for the first time.

  "You are a heroine, and a representative of women who hold up half the sky. Now you have become the ‘ of women in China; Image ambassador ’ !” During the two sessions of the National People’s Congress in 2013, General Secretary of the Supreme Leader cordially praised Liu Yang.

 The return capsule of Shenzhou-9 spacecraft successfully landed in the reserved area of the main landing site in central Inner Mongolia, and astronaut Liu Yang got out safely (photo taken on June 29th, 2012). Xinhua News Agency reporter Wang Jianmin photo

  "We are lucky to catch up with the good times of national development, and we will definitely write the honor of our motherland all over space!" Liu Yang said firmly.

  Ten years passed, and Liu Yang devoted himself to preparing for the war. In 2022, she knocked on the sky again with the Shenzhou 14 manned spacecraft.

  The sea is wide and the fish jumps, and the sky is high and birds fly.

  "On the new journey, every woman is a writer of the times and a struggler who pursues dreams. It is necessary to unite the strength of women, gather the wisdom of women, respect and care for women, guide women to actively participate in the great practice of the new era and new journey, and make new and greater contributions to building a socialist modern country in an all-round way and promoting the great rejuvenation of the Chinese nation in an all-round way. "

  Under the strong leadership of the CPC Central Committee with the Supreme Leader as the core, the vast number of women cherish the beautiful dreams endowed by the great era, and make contributions and continue to write glory in the vast world of the new journey with their lofty sentiments and hard work.

  Text reporters: Huang Yue, Dong Boting, Wang Mingyu.

  Poster design: Xie Yue

  Editor: Wang Qiuyun, Yang Wenrong, Zhang Huihui, Hao Xiaojing, Qi Wenjuan, Wang Haocheng, Wu Jinfu

  Coordinator: He Yuxin and Zhou Yongyan

The United States is the biggest black hand in the politicization of Covid-19’s scientific traceability.

  At the dark moment of mankind when the COVID-19 epidemic brought disaster and panic to the whole world, the United States, which always positioned itself as a "world leader", not only failed to lead other countries to jointly fight the epidemic and curb the epidemic of the COVID-19 epidemic, but kept blaming it, from the former President Trump calling the new coronavirus "China virus" to the US government led by the current President Biden pressuring the World Health Organization, pointing its finger at China again, resulting in increasingly politicized virus traceability. Since the outbreak of the epidemic, the United States has stigmatized the epidemic, labeled the virus and politicized the source, which violates scientific common sense and ignores the lives of people around the world. American politics manipulates the extremely serious scientific issue of Covid-19’s origin, which makes it an important means for American politicians to confuse people at home and gain political capital, and to confuse people to suppress China internationally.

  The politicization of the US pressure on WHO traceability has intensified.

  China, as the first country to report the confirmed cases of COVID-19, was also seriously injured in the early stage of the epidemic. Where did Covid-19 come from, and where did the COVID-19 epidemic break out? It needs scientific tracing work. In March this year, with the full support of China, an international expert group of the World Health Organization came to China to carry out the traceability work of Covid-19. On the basis of in-depth analysis of a large number of data, the joint research report of China was officially released, and it was concluded that Covid-19 was "extremely unlikely to be introduced by the laboratory", which pointed out the direction for the next joint traceability research in many countries and places around the world. At the same time, with the disclosure of confirmed cases earlier than Wuhan in relevant countries, the necessity and urgency of global traceability in Covid-19 are highlighted.

  However, on July 16th, the "Second-stage Traceability Work Plan" notified by the secretariat of the World Health Organization to member countries turned the investigation direction back to China. This work plan, which lacks transparency in the drafting process, ignores the most important research directions such as global early cases and cold chain-transmitted viruses, which are most concerned at present, and is contrary to the resolution of the 73rd World Health Assembly and the conclusions and suggestions of the China-WHO joint research report on traceability in Covid-19. As an international organization that leads and coordinates the global anti-epidemic, why does the World Health Organization put forward a work plan that does not conform to the conclusions and recommendations of its first-phase research report?

  In this work plan, we can easily see the shadow of the "laboratory leakage theory" that prevailed among American politicians from the Trump administration to the Biden administration. Since the outbreak of new crown pneumonia, western countries, led by the United States, have been speculating about the virus leaked by Wuhan Institute of Virology, Chinese Academy of Sciences. After the expert group of the World Health Organization has come to the conclusion that the virus is "extremely unlikely to be introduced from the laboratory", it is still biting. Biden ordered the US intelligence community to prepare a "traceability report" on the origin of the virus 90 days later on May 26th. In August this year, the investigation report of the Republicans of the Foreign Affairs Committee of the US House of Representatives on the origin of COVID-19 and Wuhan Virus Institute, "Covid-19 Origin: Investigation on Wuhan Virus Institute", once again ignored the facts and put forward the fallacy that "Covid-19 was leaked by Wuhan Virus Institute".

  From these two examples, we can easily see that the "laboratory leakage theory" is just an issue for American politicians to gain political capital at home. But there is a fatal flaw in both US President Biden’s orders and Republican reports — — The study of virus traceability is a serious scientific issue, but the report is led by politicians and intelligence personnel, based on preconceived assumptions and information that catches the wind. Such a report does not have any credibility, but is only a purposeful arrangement and combination of relevant information, which is used as a tool to meet political needs.

  Looking back at history, this is also the consistent practice of the United States. In 1993, the United States concocted the "Yinhe" incident. The United States claimed that the cargo ship Yinhe of China transported chemical weapons raw materials to Iran and stopped it in the international waters of the Indian Ocean for 33 days. The final investigation confirmed that the "Yinhe" did not carry chemical weapons raw materials, and finally it was abandoned. In 2003, the United States made a big lie about Iraq’s possession of "weapons of mass destruction" and launched the Iraq war on this ground. Now, this method has been used in the traceability of Covid-19. We don’t know what kind of political pressure the World Health Organization is under, but it needs to be clear that the virus tracing work is serious scientific work, and the "second-stage tracing plan" for the sake of "laboratory leakage theory" is "presumption of guilt" for China, and this politicization of tracing is unacceptable.

  The China part of Covid-19’s global traceability has reached a conclusion. For the second stage of traceability, China has also put forward a Chinese plan. Including taking the resolution of the World Health Assembly as the guide, taking scientists as the main body and carrying out scientific traceability based on evidence; The first stage of traceability research has been carried out, especially if a clear conclusion has been reached, and the second stage should not be repeated. The focus should be on the potential transmission routes such as "very possible" and "possible" defined by joint research reports such as animal (intermediate) host introduction and cold chain transmission, so as to promote traceability research in many countries and places around the world; Fully learn from the practice, mechanism and methods of the first phase of virus traceability work to promote the orderly and smooth development of traceability work; The expert group should be established on the basis of the first-stage traceability research experts, and fully respect the professional level, international reputation and experience of the members of the expert group.

  The United States is not qualified to be the "teacher" of virus traceability.

  Since the outbreak of the New Crown Pneumonia epidemic, the United States and its allies have been discrediting and throwing pots at China, achieving the dual goals of gaining political capital at home and suppressing China internationally. The source of the virus is global, and the initiator of the "laboratory leakage theory" should be the United States, and there are a lot of doubts to be investigated by scientists.

  For nearly 20 years, the United States has blocked the resumption of negotiations on the verification protocol of the Biological Weapons Convention on its own. In 2019, at the meeting of States parties to the Biological Weapons Convention held in Geneva, the overwhelming majority of States parties advocated the negotiation of a protocol aimed at comprehensively strengthening the Convention, including the verification mechanism. However, the United States once again blocked the resumption of negotiations on the verification protocol. The reason of the United States is that the biological field cannot be verified, and international verification "may threaten US national interests and trade secrets" and is conducive to "industrial espionage." As long as the verification mechanism is established under the framework of the Biological Weapons Convention, it can be used to constrain whether the biological laboratories of various countries comply with the Biological Weapons Convention, and it will be clear who will comply and who will breach the contract, and all problems will be solved. The United States has set up at least 200 biological laboratories in 25 countries and regions around the world, which is the country with the largest number of biological laboratories at home and abroad. What are the hidden secrets in these secretive places that make the United States strongly obstruct the resumption of negotiations on the verification protocol of the Biological Weapons Convention? The answer is meaningful.

  Since the outbreak of the epidemic, the United States and other countries have hyped China’s "laboratory leakage theory" and even discriminatively called the new coronavirus "Wuhan virus". In the first phase of the World Health Organization (WHO) virus traceability work, Wuhan Institute of Virology experienced a rigorous investigation by a joint expert group of WHO, and came to the authoritative conclusion that the virus was "extremely unlikely to be introduced from the laboratory". So, since the United States holds high the banner of "laboratory leakage theory", should its notorious and doubtful Fort Detrick laboratory be investigated by scientists?

  Fort Detrick has a P4 biological laboratory affiliated to the US Department of Defense and at the same level as Wuhan Institute of Virology in China. It is one of the most advanced research laboratories for toxins and antitoxins in the world. The people of China are victims of bacteriological warfare and chemical and biological weapons. During the Japanese war of aggression against China, the 731 troops of the Japanese army conducted a terrible bacteria test and human experiment in the northeast of China. After World War II, Fort Detrick hired Shiro Ishii, the head of Unit 731, as a senior consultant, on condition that he was exempted from being investigated for war crimes. So far, no matter how loud the international community is calling for the investigation of the Fort Detrick base in the United States, the U.S. government has always been secretive about this issue.

  In July 2019, the US Centers for Disease Control and Prevention suddenly ordered the closure of the biological laboratory at Fort Detrick military base, and the government ordered the experimental base to stop all research on the most deadly viruses and pathogens. The reason given by the official is that the inspection of the laboratory by the US Centers for Disease Control and Prevention in June 2019 found that there are worrying places in the standard operating procedures used to protect the staff of biosafety level 3 and level 4 laboratories; The biological protection laboratory did not conduct regular recertification training for employees; The steam disinfection factory in the laboratory has failed, and there is not a perfect system to purify the wastewater in its highest security laboratory. A few reasons are understated, but the behind is shocking, which means that there are long-term problems in P4 biological laboratory, which is the highest level and the most dangerous in the world. Does the United States’ obstructionism in restarting the verification protocol of the Biological Weapons Convention also mean that it has a shocking secret in its biological laboratory? If not, why not accept the virus traceability investigation like China?

  Since the outbreak of the COVID-19 epidemic, American politicians have not put people’s life and health first, but have used the epidemic as a tool to gain political capital, which has led to the failure of epidemic prevention and control in the United States. As a country with the highest public health system in the world, the United States has actually become the country with the largest number of confirmed cases and deaths in the world. Even so, American politicians still don’t put 100% energy on how to improve the prevention and control of domestic epidemic, but constantly use the COVID-19 epidemic to throw the pot and discredit China.

  How can the only country in the world that hinders the resumption of negotiations on the verification protocol of the Biological Weapons Convention, the country with the largest number of biological laboratories in the world, and the country with the largest number of confirmed cases and deaths in the world lead such a serious scientific work of virus traceability? The United States is not qualified to dictate the traceability of the virus.

  Punch the political lies of the United States in Covid-19.

  Looking back at history, human beings have always struggled with infectious diseases, from plague, smallpox and cholera to AIDS, SARS and Ebola virus. Every time an infectious disease is pandemic, human society will experience a painful lesson. However, the history of human struggle against infectious diseases is also a history full of wisdom. The pandemic of infectious diseases in the era of globalization needs the full coordination of all countries as never before. In the face of global challenges, mankind needs sincere unity as never before.

  However, from the outbreak until now, what we have seen is that the western countries, led by the United States, are full of biased, narrow and sinister political means, trying to take the new pneumonia epidemic as an opportunity to suppress China. With the manipulation of American politicians step by step, the COVID-19 epidemic has already surpassed the global epidemic of infectious diseases in a simple sense, and has become a bargaining chip for western countries led by the United States to wrestle with China. At the beginning of the outbreak, China government closed the exit passage of Wuhan, a city with a population of 10 million, with unprecedented determination, and implemented quite strict epidemic prevention and control policies, which finally made China one of the most successful countries in epidemic prevention and control. On the other hand, in the United States, politicians who are keen on party struggle have different opinions on the epidemic prevention and control policies, and the epidemic situation has gradually deteriorated in the debates in Congress. Therefore, it has become the best choice for some politicians in the United States to constantly speculate on the "China laboratory leakage theory" and shift the responsibility for the failure of epidemic prevention and control to China.

  The traceability of Covid-19 needs evidence, which should be a process of scientific proof, and requires a strict and standardized investigation by an expert team composed of authoritative scientists. Covid-19’s traceability should be global in scope, not only for China, but also for the presumption of guilt of "if you don’t find it the first time, check it several times". Only in this way can the global fight against the epidemic move in the right direction, and the end of the epidemic in COVID-19 can usher in the dawn.

  The international community must not let the political manipulation of the United States mislead the direction of the world, politicize such a serious scientific issue, and make excuses for the failure of the United States in fighting the epidemic, let alone let it pressure the World Health Organization or other international organizations. We need to debunk the political lies of the United States on the origin of the virus in appropriate occasions of the international community and on various platforms of international public opinion, so that the international community can realize that the United States is the biggest black hand in the politicization of Covid-19’s origin, and let people of all countries see clearly the political conspiracy of the United States to suppress China.

  (Ren Mengshan: Professor, Ph.D. Supervisor and Director of International Communication Research Center, Communication University of China; Chen Qiang: Ph.D. candidate in Communication, Communication Institute, Communication University of China, 2020)

"China in the Intangible Heritage" has a tour of three places and four waters, and enjoys the cultural heritage of Hunan!

  Why can’t a thin piece of aramid paper be lit with an open flame at 500℃? What role does the "wet copy method" in Cailun’s Papermaking skills play? It takes more than 1000 yarns to weave a one-foot square Dong brocade. How can the diaojiao building, which is surrounded by mountains and rivers, stand for hundreds of years? How does Xiangxi Miao drum dance combine with drum dance perfectly? What modern technology and traditional spraying principles are used in fireworks that can be touched by hand? Let’s walk into Hunan with curiosity and questions and reveal the answer ~

  Enjoy the natural landscape, appreciate the fireworks on earth, taste the beauty of non-legacy and witness the new look of the times! What kind of surprise and shock will it bring us when we set foot on the land of Hunan and Chu with unique natural environment and profound historical and cultural heritage? On June 24th, the large-scale cultural program "China in the Intangible Cultural Heritage" jointly produced by the Central Radio and Television General Station and the Ministry of Culture and Tourism will be broadcast on CCTV-1 at 20:00, and the CCTV video will be premiered exclusively on the whole network, opening a wonderful journey of "Xiang" encountering intangible cultural heritage!

  Landscape painting, meet in Chenzhou. In this program, Long Yang, the host of the reception desk, together with guests Dan Jixiang and Du Jiang, walked into Chenzhou, Hunan Province, and felt the unique Huxiang culture watered by three Hunan and four waters, witnessing the inheritance, innovation and development of Hunan’s intangible cultural heritage in the new era. Bamboo paper making skills, Miao people’s inspiration in Xiangxi, Liuyang fireworks making skills, Tujia diaojiao building building skills, Dong brocade weaving skills & HELIP; … In this famous cultural city that has witnessed a thousand years’ history, the colorful intangible cultural heritage skills are dazzling, and the infinite vitality of generate under the empowerment of the times is even more amazing, which makes people feel deeply proud!

A thin piece of aramid paper

An open flame at 500℃ will not light.

Application of "Wet Copy Method" in Cailun’s Papermaking skills

And countless researchers have been working day and night for more than ten years

For this cutting-edge technology

It is deeply branded as "Made in China"

Mei tuo, handsome boy, are you powdered?

The familiar local accent makes people return to Hunan in a second.

Delicious and spicy Qifengdu Fish Meal

Thousands of times of "beating" and "playing"

There are Yongzhou blood duck, stinky tofu, sister dumplings, triangle tofu, and eight-treasure fruit rice … …

Hunan people’s search for delicious food

Not only is it "colorful" spicy

There are more surprises and satisfaction.

Innovative and reformed "New Life-Red Loom"

Realizing the transformation of loom from tool to art.

The luminous Dong brocade woven from it.

With unique charm and lasting vitality

Let people all over the world see the contemporary development of China’s intangible heritage.

Stand in a dangerous place and blend in with the mountains and rivers.

Do not need any sophisticated tools.

The ink master only uses the sample manuscript and uses Luban characters that only carpenters can understand.

You can build a dry-column style Tujia diaojiao building.

These architectural wonders that have stood for hundreds of years

The wisdom contained in China makes people proud and amazes the world.

Inspiring Miao people’s encouragement

Most of the movements are based on daily life and work.

The warm and powerful drums and dances.

It can always arouse the deep strength of the Miao people in western Hunan.

It also aroused people’s yearning for the land of Xiangxi.

A flower drum, a play in the cup.

The fancy cup-beating in Changsha Huagu Opera is not fun.

Xiangfeng embroidered language, lifelike.

A stitch and a thread embroider a "real" world like magic.

There is also the silver jewelry forging technique of "seamlessly connecting one piece with another"

And Miao costumes with unique national styles.

In Chenzhou Changjuan Intangible Cultural Heritage Block

There are stunts everywhere, and the ingenuity is seen step by step.

From the early poverty-stricken counties to the top 100 counties in China.

Liuyang’s gorgeous turn is inseparable from the continuous exploration of fireworks.

When traditional skills collide with modern technology

More diverse, more gorgeous, more environmentally friendly and more useful.

Become the future development direction of Liuyang fireworks.

In the creative show jointly created by china opera,

Hunan’s non-legacy skills are "alive"

In the quiet and vast sea of bamboo

The dancers’ powerful movements.

Deduct the story of a bamboo turning into a piece of paper.

"Dong" can see everything.

Dancers change back and forth in criss-crossing silk threads.

The fineness of the thread is above the Dong brocade.

Accompanied by bursts of drums

Dancers are dancing in the mountains and rivers.

Show the shock and beauty of Miao nationality’s drum dance in Xiangxi together.

On June 24th, CCTV-1 at 8 pm.

Walking into China in the Intangible Heritage

Hunan is a legacy, and it is wonderful!

"Xiang" encounter trip, be there or be square!

[Ten years after the Wenchuan earthquake] Thousand-year-old red bean trees sprouted new branches after the earthquake

 Hongdou Village, Shigu Town, shifang city, successfully embarked on the road of industrial transformation after the Wenchuan earthquake and was awarded as a national civilized village. (He Chuan/photo)


Hongdou Village, Shigu Town, shifang city, successfully embarked on the road of industrial transformation after the Wenchuan earthquake and was awarded as a national civilized village. (He Chuan/photo)


Cctv.comnews(Reporter) He Chuan) The village is named after the tree, and the tree is because of the village.feeling.

 

ten years agoofThat day, the vibration roared from the ground and swept through Shu.middle. In Hongdou Village, Shigu Town, shifang city, a thousand-year-old red bean leaves fell like rain.Cry like a cry.. decadecomeThis ancient tree witnessed the change of Hongdou Village bit by bit.See the vicissitudes of life and listen to the joy of the world..

Pan Yunqin, who grew up under an old tree, found that the old tree had sent out some new branches in the past ten years, which had never been seen in previous decades. (He Chuan/photo)

Pan Yunqin, who grew up under an old tree, found that the old tree had sent out some new branches in the past ten years, which had never been seen in previous decades. (He Chuan/photo) 

Things have changed, and old trees have sprouted new branches in ten years.

 

On May 4, 2018, the 10th anniversary of the Wenchuan Earthquake, the national online media trip to Sichuan entered Hongdou Village. The reporter found an old man looking up for a long time under the Millennium red bean tree and refused to leave. Upon inquiry, I learned that the old man’s name is Pan Yunqin, and he is 78 years old. Pan Yunqin told reporters: "My family used to live under this red bean tree and watched it every day since childhood. I moved to my new home, but I still miss the old tree, so I have feelings. Every day when I’m free, my wife and I will take a look around. There are some changes that you outsiders can’t see, just below the right side of the big tree fork at the bottom. In the past ten years, some new branches have come out. "

 

Old trees have sprouted new branches, and Hongdou Village has taken on a new look.

 

In WenchuanBefore the earthquake,Hongdou villageVillagehave806 households2384 people. Village2249 mu of cultivated landofTwo-thirds grow cigar tobacco leaves, with an output value of about per mu.5,000 yuan is the main source of income for the villagers.

 

Farming in the farming season, living quietly in the leisure time."That day" was completely broken: houses collapsed, farmland was damaged, and 6 people were killed and 35 injured in the whole village., production and life instantly stagnated..— — Today, local villagers alsoA little shy about talking about that date,Mention it.useThe word "that day"To replace.

 

In the second year of post-disaster reconstruction,On September 22nd, 2010, Millennium Red Bean witnessed the first great event after the earthquake.

 

At that time, the villagers in Hongdou Village had moved from the prefabricated houses to their new homes:Vegetable beds are surrounded by western Sichuan folk houses.Sihe yardThe traditional wedding scenery of China, built around the Millennium red bean tree, blooms..Since the whole countryIn all directions,Having participated in earthquake rescue and post-disaster reconstruction.99 pairs fromTroops and placesofnewly-marriedTake red beans as evidence, swear each other’s engagement,Will be the most important thing in lifeofThe process stayed in this place with special commemorative significance.

 This is the new home of the old couple Pan Yunqin, and the yard next to them is their son's home. Ten years later, the villagers in Hongdou Village returned to an idyllic and peaceful life. (He Chuan/photo)


This is the new home of the old couple Pan Yunqin, and the yard next to them is their son’s home. Ten years later, the villagers in Hongdou Village returned to an idyllic and peaceful life. (He Chuan/photo)

After the collective wedding, Hongdou Village became famous and brought a large number of tourists. However, people can’t find a place to eat and go to the toilet, so they can only rush by.Some newcomers want to hold a wedding in Hongdou Village, but the village has no ability to undertake it.,Many newcomers just come here to take wedding photos on location.

 

So, around this thousand-year-old tree, Hongdou Village changed from the hometown of tobacco leaves to the hometown of love: that year,In November,Five enterprises invested a total of 24 million yuan,Weihongdou villageCreate facilities such as flower nursery, leisure and entertainment, catering and accommodation. The Millennium red bean tree has become a sacred place for newlyweds to promise each other for life, and jewelry made of red beans has also been popular among young people.Farmhouses and teahouses have mushroomed. After the successful transformation, Hongdou Village welcomed the special care of lovers all over the country.

 

According to reports, Hongdou Village has been rated asNational civilized village, and selected as a traditional village in China.Directory, as ofthe year 2017Bottom,Annual per capita disposable income of villagersreach16,500 yuan.

The port opens the Wan Li stream | Jining "enters the market": a new force surging in the canal

  Public Network Poster Journalist Wang Shuangai Correspondent Yao Wang Lu Guanyi Jining Report

  In ancient China, waterway was the most commonly used long-distance transportation mode. Therefore, the long journey of sailing along the river has naturally become an opportunity for prosperity. Natural rivers shine brightly in the trade between business travelers, showing all kinds of ups and downs.

  "Huairou Baishen, and the Qiao Yue River, allow Queen Wang Wei." Every river has a story flowing.

  Especially the canal.

  In 2021, the world-class "golden artery" of the Suez Canal was blocked by a "ship" of Ever Given. Although it took a week to get stranded and get out of trouble, no one seemed happy except the small excavator that fought alone. The 18,000 containers on board not only test how to save time and money as much as possible in the transportation process, but also face a series of "price increase" problems after the supply chain balance is broken.

  According to rough statistics, more than 80% of the world’s trade activities are carried out by sea, and the international situation is slightly "nothing happens", so the pressure on maritime shipping naturally increases exponentially.

  Inland river transportation and maritime transportation belong to waterway transportation.

  China has a long coastline, numerous harbors, and a great river crossing the east and west. These natural rivers and lakesides are abundant in water, most of which are not frozen all year round, and most of the main navigable rivers are distributed in economically developed and densely populated areas. The unique resource advantages are very conducive to the establishment of estuary ports with economic value.

  The Grand Canal runs through Weishan Lake. Chen Baocheng/photo

  Counting the main inland shipping trunk lines in China, besides China’s "golden waterway" Yangtze River, South China’s water transport artery Pearl River, Heilongjiang and Songhua River, a Beijing-Hangzhou Grand Canal that makes up for China’s lack of north-south vertical natural waterway will surely occupy a place. If we want to focus on how to solve the structural contradiction of relatively low waterway transportation in domestic river sections, the section from Jining to Hangzhou in Shandong Province of the Beijing-Hangzhou Grand Canal is a typical case like a textbook.

  With the help of the inland container shipping outlet of the Grand Canal, we firmly grasp the hope of urban transformation, and Jining, a city along the route, has the most say.

  Resource-based cities, turning around on the spot

  Jining is a typical resource-based city.

  From the industrial point of view, Jining, with an annual output of 80 million tons of raw coal, is one of the 13 large-scale coal production bases and 7 coal chemical industrial bases planned and constructed by the state. For a long time, Jining’s coal industry has been dominant, and its shortcomings such as biased industrial structure, weak demand power, weak innovation drive and insufficient factor support have gradually become prominent. What is more predictable is that in the next two or three decades, Jining’s coal mines will gradually run out of resources.

  How to transform resource-based cities? How to boost the social economy? Where should industrial workers closely related to coal go?

  Holding more than 10,000 coal mine workers, Jining Energy Development Group "took the lead" and stood on the "gateway" of transformation. Although all the opportunities related to proper resettlement are worth grasping at present, Jining Energy Development Group has ushered in a real benefit: the establishment of Jining Port and Shipping Development Group.

  Wang Chuanjun, Shipper of Liangshan Port Wharf/photo

  In May 2020, Jining Port and Shipping Development Group, with Jining Energy as the main body, was formally established, with the goal of anchoring and building the largest inland river shipping center in the north. By the end of 2021, Jining Port and Shipping Development Group has successfully completed the integration of three ports: Sendamei Yuejin Port, Longgong Port and Taiping Port, highlighting the construction of three hundred million-ton port groups: Liangshan Port, Main City Port and Weishan Port.

  Among them, Liangshan Port is on the Wari Railway and next to the Beijing-Hangzhou Canal, occupying the throat of transporting coal from the west to the east, absorbing high-quality coal resources from Shanxi, Shaanxi and Mongolia, connecting with East China and Central China along the canal, directly entering the hinterland of the Yangtze River, radiating Jiangsu, Zhejiang, Shanghai, Hubei, Chongqing and Hunan, and becoming an important port logistics hub connecting the western coal source areas and the Yangtze River Delta Economic Zone. At present, eight 2,000-ton berths, 100,000 TEU container terminals and the largest span steel structure coal storage shed in China have all been put into operation.

  Longgong Port aims to build the largest intelligent container demonstration port in Jiangbei inland river, and an automatic control center will be built, which will improve the working efficiency by 80%.

  Gathering production in Hong Kong and integrating production in Hong Kong.

  From January to June, 2022, the operating income of Jining Energy Port and Shipping Plate was 15.656 billion yuan, 5.6 times that of the same period last year, the port throughput was 9.3201 million tons, up 57.52% year-on-year, and the container transportation was 20,700 TEUs, 11 times that of the same period last year.

  Jining Energy Port Container Brand

  Canal, container port and port logistics constitute the three key words of Jining’s "turning around on the spot". Even if it closes a "door" where the volume and price of the coal industry are rising, this resource-based city is trying to open another "window" for port and shipping logistics to upgrade.

  Through combined transport of hot metal and water, the river reaches the sea.

  "It should be that Heaven teaches to open the water, and there are no mountains in more than a thousand miles." Ever since Fu Cha, the king of Wu, dug a ditch and shoveled the first shovel of soil, the Beijing-Hangzhou Grand Canal has been very minimalist. Among many rivers and lakes in China, she flows through eight provinces and cities, with a total length of about 3200 kilometers. These layouts are like blank spaces in Chinese painting, full of charm.

  After 2500 years, the texture is still the same, and the Grand Canal is still the same. Coincidentally, the most important thing about the Beijing-Hangzhou Grand Canal is the sense of youth: whether it was the first time in April this year that the entire line was opened to water, or the 62-kilometer interconnection and experimental navigation of the entire Beijing-Hebei section of the Grand Canal in June, or the Liangshan Port along the Grand Canal was only "7 years old".

  In Jining’s view, Liangshan Port is purely "out of thin air", but it is particularly "indispensable".

  Liangshan Port started construction in April 2015, and was included in the key construction projects in Shandong Province, the coal emergency reserve base in Shandong Province and the multimodal transport demonstration project in Shandong Province. In order to get through this key node, Jining Energy excavated 17.1 kilometers of waterway and built 9.18 kilometers of special railway line, connecting the Wari Railway with the Beijing-Hangzhou Canal, and realized the multimodal transport of public iron and water.

  As the northernmost section of the Beijing-Hangzhou Grand Canal, Jining Energy Liangshan Port is now a rapidly rising inland shipping port in Shandong Province, and has been praised by the industry as a "coal mine on the ground" that does not produce coal. With the help of the low cost of container inland transportation, which is only one third of the cost of road transportation, and tapping the water transport potential of the Grand Canal, Liangshan Port has taken advantage of the east wind of the national "double cycle" strategy, which has increasingly strengthened economic communication and trade between inland areas and coastal areas, and the freight volume has risen sharply.

  In September 2021, Liangshan Port opened scheduled container routes from Jining to Wuhan, Taicang (Shanghai), Nanjing, Huai ‘an and Lianyungang, which can reach Taicang in 5 days and Wuhan in 10 days. After the overall completion of the project, it will have a handling capacity of 50 million tons, completely opening up a new channel for logistics and transportation of bulk goods such as upstream coal.

  Longgong Port, located next to the main channel of the Grand Canal, aims to build the largest intelligent container demonstration port in Jiangbei inland river, and introduces the "seaport concept" into inland river ports to build a specialized and highly automated container port, thus opening a new mode of green and intelligent container transportation in Jiangbei inland river.

  Construction scene of Longgong Port

  At present, the construction of 6#-8# container berths in Longgong Port is speeding up, and it will be put into operation smoothly at the end of July, reaching the annual handling capacity of 300,000 TEUs, which will vigorously promote the "revolution of water" and "scattered collection" of bulk goods, and the transportation cost per ton of goods can be reduced by more than 30% compared with that of public rail transportation. By building a container multimodal transport project, after all the 10 berths and special railway lines in the second phase are put into operation, the annual throughput of 800,000 TEUs of containers and 1 million tons of groceries will be realized, and the annual throughput will exceed 20 million tons. It will become the first port in Jiangbei inland river to realize unmanned shore bridge, electrified transportation and automatic yard bridge.

  Liangshan port special railway line, the train is coming into the station.

  With the established trend, more and more attention has been paid to the planning of river transport and river access to the sea.

  In Jining City alone, this year, relying on four key ports, nearly 10 projects have been planned and constructed, including the intelligent container terminal project of Longgong Port, the new energy ship manufacturing base of port and shipping, the transportation equipment and container manufacturing base of port and shipping, and the metal material processing base of Liangshan Port.

  By 2025, it is expected that the whole city will gradually realize logistics trade as the guide, and build a modern port and shipping logistics industry chain covering eight major businesses, including port operation, shipping, port and shipping engineering construction, commodity trading, supply chain finance, new energy ships and container manufacturing, intelligent logistics information service and integrated logistics, build a 100 million-ton port, develop 100 million-ton logistics, cultivate 100 billion industries, and build "China Northern Inland River Shipping Center" and "Jiangbei Commodity Trading Center".

  Jining energy Liangshan port Jinghang multimodal transport logistics zone

  At the same time, Jining plans to build five industrial parks, such as Liangshan Jinghang multimodal transport logistics park, Longgong container demonstration park and Yuejin Lingang industrial park, which will further cultivate and expand the producer service industry and help multimodal transport show its super power.

  In February of this year, the 14th Party Congress of Jining put forward "unswervingly implementing the breakthrough strategy of modern port and shipping logistics", adjusted and established the modern port and shipping logistics development headquarters, and demanded that the whole city make efforts to develop modern port and shipping logistics, promote inland shipping to break the obstruction, expand capacity and upgrade, and fully revive, build Shandong into a bridgehead open to inland and international, and strive for a port-type national logistics hub.

  Jining Towing Team (No.2836) originating from Liangshan Port and heading south in the sunset Wang Chuanjun/photo

  Nowadays, Jining continues the profound port and shipping culture, and relies on a full range of shipping elements to reproduce the prosperous scene of "officials, merchants and ships gather together, and hemp is under the economic city".

  Interestingly, Jining has a different perspective every time it "screens", which reminds us repeatedly about the profound charm and proud responsibility of this city. When Jining dedicated her blood to the 20th National Congress of the Communist Party of China, we were even more surprised by her optimism, composure, wisdom and limitless future.

Source: Public Network

Synthetic Biology: Igniting the New Engine of Future Production

The article comes from the precision home, by BiomedLink.

01Synthetic biology opens a new era of "creation"

Synthetic biology, known as the important carrier of the "third biotechnology revolution", is a new interdisciplinary subject in the 21st century. Its essence is to make cells work for human beings and produce desired substances. With this technology, many products we come into contact with in our daily life can be synthesized in the form of biological methods.

For example, the synthesis of artemisinin, whether it is extracted by planting Artemisia annua in large quantities or synthesized by chemical methods, is limited and costly.

In 2005, Amyris company obtained artemisinin by synthetic biology technology, and then obtained artemisinin by chemical synthesis, which greatly improved the output of artemisinin. After cooperating with pharmaceutical giant Sanofi, artemisinin achieved mass production.

According to the data of Industrial Securities, the price of artemisinin dropped from nearly $1,200/kg in 2005 to below $200/kg in two years. It can be seen that the application of synthetic biology can not only improve the product yield, reduce the cost and produce high-value products, but also reduce the damage to the environment caused by planting raw materials or breeding animals, which meets the market requirements of green development. 

In recent years, many traditional and emerging enterprises have deployed in the synthetic biology track, and a large number of enterprises in the field of synthetic biology have been born at home and abroad, which have successfully won the favor of the global capital market, which has also expanded the scale of industrial investment and financing.

Thanks to the technical breakthrough and the support of funds and policies, synthetic biology has made a breakthrough in just a few years, and quickly developed its scientific research achievements into practical industrialization, which is widely used in medical, chemical, cosmetics, materials and other fields, and is expected to solve the bottleneck faced by resource problems in these fields.

According to McKinsey’s statistics, it is estimated that by 2025, the economic value of synthetic biology and bio-manufacturing will reach 100 billion dollars, and 60% of the world’s material production in the future can be realized by bio-manufacturing.

02Driving synthetic biologyThe underlying technology of development

Synthetic biotechnology is the application of engineering thinking in the field of biology, which continues the technology based on recombinant DNA, and integrates cell engineering, metabolic engineering and other related technologies, with enzyme catalysis as the core and the goal of creating a new life system.

Key underlying technologies include DNA sequencing, DNA synthesis, DNA editing and gene expression regulation.The rapid progress of the underlying technology and the continuous cost reduction have significantly improved our ability to design and transform DNA, RNA, protein and cell expression forms, and greatly promoted the development of the industrialization of synthetic biology. 

DNA sequencing technology 

As the core of "reading", the genome sequence of each species is cracked at the DNA level, which reveals the genetic basis of biodiversity in nature and lays a data foundation for finding a powerful "tool" for synthetic biological manufacturing. This technology began in 1970s. At present, the second and third generation sequencing technologies are the mainstream technologies of DNA sequencing, which can realize millions of sequencing reactions at one time.

DNA synthesis technology 

Refers to the synthesis of DNA from scratch, which has many unique advantages. Because it is easier to achieve the goal by synthesizing DNA from scratch, and a complete template can be obtained for amplification and modification; The sequences synthesized by artificial optimization are superior to natural sequences, which is helpful for studying genetic mechanism. Some hypotheses can be designed and tested by using these synthetic sequences. In recent years, using the high selectivity and catalytic activity of enzymatic reaction to develop template-independent enzymatic DNA de novo synthesis technology is expected to further improve the efficiency of one-step synthesis, but it is still in its infancy and there are still many problems to be overcome step by step.

Gene editing technology 

It is a genetic-related operation technology that modifies DNA sequences at the genome level. The principle is to cut off DNA at the target site by an artificial endonuclease and induce the DNA repair system in the cell to start. At this time, gene editing technology can realize site-specific gene knockout, specific mutation introduction and site-specific modification.

Gene expression regulation 

It is one of the core technologies of metabolic engineering and synthetic biology, and plays a vital role in optimizing the efficiency of the synthetic pathway of target products, avoiding the accumulation of excessive metabolic intermediates and improving the productivity of synthetic cells. It is the simplest and most effective way to realize intracellular gene expression by changing the intensity of corresponding gene expression regulatory elements (such as promoters and terminators). At present, corresponding databases have been built for typical model microorganisms to provide different strength and types of regulatory elements. In addition, the regulation of gene expression can also be achieved by using specific proteins or RNA that control global gene expression and adding inducers for dynamic regulation. The existing problems of this technology include insufficient specificity of natural response elements, difficulty in modification and optimization, non-uniform development standards of gene expression regulation tools, and the technology has not been successfully realized from concept verification to industrial large-scale application.

Genome-scale metabolic network model 

Relying on massive biological data, establishing a digital cell model at the level of the whole cell system can enable us to describe and simulate the metabolic process of life on the computer. This technology is helpful to understand the organization principle of cell system and the evolution law of life generation, and then predict the influence of various environmental conditions and gene disturbance on cell function, and guide the design of artificial life. The challenge is that it is difficult to obtain accurate kinetic quantitative data for many biological processes at present.

03World-renowned synthetic organismsEnterprise introduction

The industrial chain of synthetic organisms as a whole can be divided into three categories: upstream bottom technology, midstream platform and downstream end products.

upstreamMainly for companies that provide low-level technologies such as DNA synthesis and gene editing;

middle reachesIt is a platform company with strain transformation and automation platform as its core, and provides an efficient and reusable technology platform by integrating corresponding technologies;

lower reachesIt is a product-oriented company that uses synthetic biology technology to produce products needed in various fields. 

AmyrisIt is the first Nasdaq listed company in the field of synthetic biology, and also the originator and typical representative of platform companies. After long-term industrial exploration, it has gradually become an influential producer of farnesene and long-chain hydrocarbons. Its strain transformation platform is one of the earliest engineering platforms in the industry, and its functions include DNA design, DNA assembly, DNA quality control, strain transformation, Qualcomm screening, data analysis and amplification experiments. The company’s business includes cleaning and beauty, health care and spices. 

GinkgoBioworksIt was listed in May, 2021. Headquartered in the United States, it focuses on the design and production of industrial microorganisms by genetic engineering. With extensive code base, strain engineering, protein engineering and fermentation platform, we can produce and evaluate strains in Qualcomm and customize microorganisms for customers. In 2022, GinkgoBioworks completed the acquisition of Zymergen to integrate its powerful automation and software capabilities, as well as its rich experience in various bioengineering methods, which significantly expanded its synthetic biology platform. 

TwistBioscienceFor American listed companies, a new generation of silicon-based DNA synthesis platform with Qualcomm capacity and low cost has been established. This platform can synthesize a large number of high-quality DNA fragments and genes for drug development experiments and clinical diagnosis, and creates a new method for silicon chips to "write" DNA to make synthetic DNA. The main business includes health care-related, pharmaceutical research and industrial chemicals. 

SynthegoFounded in 2012, it is a genome engineering company headquartered in Silicon Valley, California. We are building a platform for large-scale scientific research through machine learning, automation and gene editing. The cloud software platform Antha is a computer-aided biological software platform, which can automatically program laboratory equipment, protocols and technological processes. The company’s main business includes using CRISPR gene engineering to transform cells, providing synthetic RNA solutions and providing bioinformatics. 

Kaisai biologyFounded in 2000, it is a platform company that has mastered the technologies related to genetic engineering and strain culture in the upstream of the industrial chain, and has completely laid out the whole industrial chain in the biochemical field from genetic engineering, strain culture, biological fermentation, separation and purification, chemical synthesis and application development, and was listed in science and technology innovation board in August 2020. At present, the main products include biological long-chain diacid, bio-based nylon and so on. 

Huaheng biologyFounded in 2005, it is a high-tech enterprise with synthetic biotechnology as its core, mainly engaged in the research, development, production and sales of amino acids and other bio-based products, and was listed in science and technology innovation board in April 2021. Products include alanine series products, D- calcium pantothenate and α-arbutin, which can be widely used in many fields such as daily chemicals, medicines and health products, food additives, feeds and so on. 

Yikelai biologyFounded in 2015, it is mainly engaged in the research and development of synthetic biological methods and large-scale production. At present, the company’s synthetic biology technology is mainly used in biomedicine, green agriculture, nutrition and health and other fields with good market prospects, and has realized the industrialization of more than 10 products. Products in the biomedical field mainly include sitagliptin intermediates, dulutvir intermediates, etc. Products in the field of green agriculture mainly include: S- cyanohydrin, amino acid oxidoreductase, etc. Nutrition and health products mainly include nicotinamide mononucleotide raw materials. 

Blue crystal microorganismFounded at the end of 2016, it is committed to designing, developing, manufacturing and selling new bio-based molecules and materials, including biodegradable materials PHA, regenerative medical materials, new functional ingredients of beauty cosmetics, new food additives, engineering probiotics, etc. It is a leading manufacturer of biological functional molecules and new materials in China.

FinishingYang Yating?

CompilationPineapple cake?

References:

1.https://baijiahao.baidu.com/s? id=1746371091974333725&wfr=spider&for=pc

2.https://finance.sina.com.cn/jjxw/2023-04-03/doc-imypansm3403195.shtml

3.https://news.sciencenet.cn/htmlpaper/201231214535563122908.shtm

4.https://www.cn-healthcare.com/articlewm/20220210/content-1313556.html

5.https://mp.weixin.qq.com/s/ebOrb_bAEaqdefWQLBnS4Q

6.https://baijiahao.baidu.com/s? id=1752342590501278814&wfr=spider&for=pc

7.https://baijiahao.baidu.com/s? id=1745942561710569700&wfr=spider&for=pc

8.https://www.cn-healthcare.com/articlewm/20220220/content-1316981.html

"Dangerous City Fighting Tyrant" exposes the trailer, Liu Qingyun swings the long whip, Gu Tianle becomes the villain


    1905 movie network news On June 17, Hong Kong director Chen Musheng’s latest action film held a press conference in Shaoxing, and the whole creative lineup was exposed for the first time. In addition to director Chen Musheng, action director Hung Jinbao, starring Liu Qingyun, Gu Tianle, Peng Yuyan, Yuan Quan, Jiang Shuying, Wu Jing, etc. also appeared.

    Afterwards, Chen Musheng teamed up with Hong Jinbao for the first time to challenge the shooting of an ancient action movie. At the scene, the film released a trailer for the film. "Destroying Tyrants in a Dangerous City" tells the thrilling story of a group of people in the rivers and lakes in a dangerous city in the early years of the Republic of China. Liu Qingyun plays the head of the Dangerous City Defense Team in the film. After many years of filming an action scene, Liu Qingyun felt fresh: "I feel like a child on the set, and I have a lot to learn." In the trailer video, Liu Qingyun fights the enemy with a long whip. He said that this time he played against the masters in "Destroying Tyrants in a Dangerous City", and the play was quite enjoyable. As for whether the whip is good or not, he has to leave a suspense for everyone to find the answer in the movie.

    Chen Musheng’s film, with Liu Qingyun, naturally cannot be without Gu Tianle. This time, Gu Zai played a villain: "He is a lonely Young Marshal who has killed a lot of people." Referring to the challenge of his old partner Liu Qingyun’s play, he laughed: "It was the first time I watched Liu Qingyun shoot ancient costume action scenes since I was a child. He was very afraid of wearing a hood and worried that he would look strange. Maybe the director promised him not to use it this time [wearing a hood] so he acted."

    In addition to Gu Tianle, there is also a villain expert in the film, that is, Wu Jing, who has been popular with his recent works. This is also his subsequent role as a villain in Chen Musheng’s works. However, Wu Jing revealed: "In fact, none of us (all the stars) are good people!" This revelation was also confirmed by Chen Musheng: "Every character has his own personality, and they may all become villains at some point." Gu Tianle also believes that Chen Musheng wants to convey in "Dangerous City Fighter" that everyone has two sides, not just the dark side.

    Compared with the above three male actors, Peng Yuyan’s look in "Dangerous City Fighting Tyrant" is the most subversive. He has always been handsome in this movie, growing a beard and braids, and playing a rough rogue in the world. "I think this role is pretty good, you can shoot directly without makeup when you wake up." In the eyes of others, Peng Yuyan sacrificed his image for the play, but he thinks this look is quite handsome: "I have always wanted to shoot a movie directed by Chen Musheng, and I feel very man. I believe I can bring you a different state this time.

    Yuan Quan and Jiang Shuying, the only female characters in the hormonal lineup, also have their own strengths and weaknesses. Yuan Quan plays Liu Qingyun’s wife, who is heroic in kung fu; Jiang Shuying plays the teacher, who is a gentle and graceful woman with a strong heart.

    The film began filming in Shaoxing in April, and the crew deliberately spent a lot of manpower and material resources to build an "ancient city" of the Republic of China that is exactly the same as in the film. At present, the main part of the film is basically completed. The filmmakers expressed the hope that "Anxious City Anxious City Anxious Tyrant" can meet audiences in the summer of 2016.